Jimmy Fallon Guests October 21, 2026

Episode clips

Uma Thurman

Interview

Uma Thurman Had a Terrifying Brush with the Law When She Was Three | The Tonight Show

Uma Thurman discusses returning for season two of Dexter and shares a frightening childhood story about a brush with the law. She also talks about gardening, including advice from Martha Stewart.

#UmaThurman ended up in the back of a cop car at three years old 😭 #FallonTonight

Josh Charles

Interview

Josh Charles on Getting Headbutted by David Wells & Playing a Blood-Phobic Surgeon in Best Medicine

Josh Charles recalls singing David Bowie at a charity karaoke event and tells stories about baseball, including being headbutted by David Wells. He also discusses playing a blood-phobic surgeon in Best Medicine.

Queens of the Stone Age

• Perfecth · View album →

Musical Performance

Queens of the Stone Age: Where The Goth Girls At? | The Tonight Show Starring Jimmy Fallon

Queens of the Stone Age perform “Where the Goth Girls At?” from their upcoming album Perfecth.

Other episode clips

Monologue

Trump Thirsts Over Sen. John Husted, White House Officials Believe Democrats Will Sweep the Midterms

Jimmy Fallon jokes about Donald Trump commenting on Senator Jon Husted’s appearance and adding an indoor pool, ballroom and patio to the White House while the midterm elections approach.

Other

Jimmy Feeds the Tonight Show's Pet Fish | The Tonight Show Starring Jimmy Fallon

Jimmy Fallon feeds the Tonight Show’s pet fish, Bubbles, while the routine turns into a comic conversation about horoscopes, shopping and everyday annoyances.

FAQ

Who were the guests on The Tonight Show Starring Jimmy Fallon on Oct 21, 2026?

Uma Thurman, Josh Charles, and Queens of the Stone Age were the guests on this episode.

When did this episode air?

Oct 21, 2026.