
The Daily Show examines Kash Patel’s denials about excessive drinking, a Jordan Klepper report on young Republicans, and the Labor secretary’s unusual family-related controversies.
Monologues, interviews, and musical performances from the previous night.
Tuesday, April 21, 2026
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Daily Show: Host: Michael Kosta · Guest: Noah Wyle
Fallon: Nikki Glaser, Jesse Tyler Ferguson, Ella Stiller, Isabel Hagen
Colbert: Neil deGrasse, Raye, John Kerry

The Daily Show examines Kash Patel’s denials about excessive drinking, a Jordan Klepper report on young Republicans, and the Labor secretary’s unusual family-related controversies.

Jimmy Fallon jokes about Trump’s claims on Iran, the stalled ceasefire, and the administration’s political messaging, while also mocking the president’s confidence that he would have handled past wars better.

Jimmy Kimmel jokes about Trump’s Iran ceasefire and White House controversies, including his Bible reading, Tucker Carlson’s political apologies, and the administration’s shifting explanations for the news of the day.

Seth Meyers stages a surprise inspection of his monologue writers, joking about the hundreds of discarded jokes produced each day and the absurd reasons some punchlines fail to make the show.

Noah Wyle discusses The Pitt and its focus on the human experience inside an emergency room, including the emotional demands of making the series. He also reflects on the show’s realism and the responsibility of portraying medical workers.

Nikki Glaser discusses losing her voice at Coachella, Leonardo DiCaprio sending her baskets of pasta after the Golden Globes, and the dating and celebrity stories that become material for her comedy.
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Neil deGrasse Tyson discusses extraterrestrial life, how aliens might judge humanity, and why people imagine visitors from space as hostile.
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Jon Favreau discusses directing The Mandalorian and Grogu, the Star Wars film’s theatrical release, and balancing large-scale production with character-driven storytelling. He also talks about directing Martin Scorsese and casting decisions across his career.

Aubrey Plaza discusses co-creating and starring in the animated series Kevin, her Mafia Kittens project, and the unusual ways she approaches comedy. She also talks about asking Seth Meyers to help deliver her baby and her experiences at the WNBA draft.
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Jesse Tyler Ferguson recounts accidentally going to a gentlemen’s club believing it was a Pilates studio and discusses turning the embarrassing mix-up into a story. He also talks about family life and reaching his fiftieth birthday.
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James Taylor reflects on performing as a teenager, the Beatles’ role in launching his career, and his early musical influences. He also discusses touring with his all-star band and the songs that shaped his long career.
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Gaten Matarazzo discusses Pizza Movie, his Hulu comedy, and life after Stranger Things, including his plans to work more behind the camera. He also tells stories about trying to stay anonymous and making the film with friends.
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Ella Stiller discusses growing up in New York, visiting the Friends fountain with Lisa Kudrow, and the unusual experiences that came with being the daughter of Ben Stiller and Christine Taylor.

John Kerry discusses how Trump’s Iran negotiators should approach diplomacy, arguing for patience and reason while explaining the stakes of the conflict. He also reflects on the role of negotiation and American foreign policy.

Dan Bucatinsky discusses The Comeback’s return and how the show’s satire now reflects artificial intelligence, celebrity culture, and changing television production. He also talks about working with the series’ cast and executive-producing the revival.
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RAYE performs “Joy” with Amma and Absolutely on The Late Show.

RAYE performs “Click Clack Symphony” from her album This Music May Contain Hope.

James Taylor performs “That’s Why I’m Here” with the house band.